Journal article
Risk of pancreatic cancer in breast cancer families from the breast cancer family registry
E Mocci, RL Milne, EY Mendez-Villamil, JL Hopper, EM John, IL Andrulis, WK Chung, M Daly, SS Buys, N Malats, DE Goldgar
Cancer Epidemiology Biomarkers and Prevention | AMER ASSOC CANCER RESEARCH | Published : 2013
Abstract
Background: Increased risk of pancreatic cancer has been reported in breast cancer families carrying BRCA1and BRCA2 mutations; however, pancreatic cancer risk in mutation-negative (BRCAX) families has not been explored to date. The aim of this study was to estimate pancreatic cancer risk in high-risk breast cancer families according to the BRCA mutation status. Methods: A retrospective cohort analysis was applied to estimate standardized incidence ratios (SIR) for pancreatic cancer. A total of 5,799 families with >1 breast cancer case tested for mutations in BRCA1 and/or BRCA2 were eligible. Families were divided into four classes: BRCA1, BRCA2, BRCAX with >2 breast cancer diagnosed before a..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work was partially supported by the Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, MINECO, Spain (#PI09-02102). BCFR was supported by the National Cancer Institute, NIH under RFA # CA-06-503, and through cooperative agreements with members of the BCFR and Principal Investigators, including Cancer Care Ontario (U01 CA69467), Columbia University (U01 CA69398), Fox Chase Cancer Center (U01 CA69631), Huntsman Cancer Institute (U01 CA69446), Cancer Prevention Institute of California (U01 CA69417), University of Melbourne (U01 CA69638), and Research Triangle Institute Informatics Support Center (RFP No. N02PC45022-46).